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Q: What Makes RESILIÉLLE Exosomes Excellent?
A: The Age Zero Certification

The source of the Age-Zero™ stem cell is a key factor in understanding the potential “cargo” and Age-Zero potency of the Age-Zero™ exosome. By employing ethically sourced Stem Cells (hUMSC), Resilielle captures released exosomes specifically targeted for skin and hair rejuvenation.

RESILIÉLLE's proprietary patent pending end-to-end USA manufacturing process including our own certified ISO 7 Clean labs with GLP, and cosmetic cGMP standards ensure the science-backed quality of every RESILIÉLLE Age-Zero product. 

As the first refrigeration-stable topical exosome skincare and haircare product on the market,
RESILIÉLLE Age-Zero products do not need to be kept frozen and were intentionally developed for topical application both post-procedure and through at-home daily maintenance.

RESILIÉLLE’s Age-Zero in-office product is packaged in easy-to-use, sealed sterile vials for one-time use, and our home care daily serum stored in a home refrigerator maintains the integrity of the formulation.

RESILIÉLLE Age-Zero post-procedure system has been shown to effectively address skin concerns from both intrinsic and extrinsic aging, returning the skin to a healthier looking state.

Frequently Asked Questions

  • What are in Resilielle Exosome Vials? How are Age-Zero Exosomes the Highest Quality Topical Exosome?
    Resilielle Age Zero Exosomes : 2. 5 Billion | 5 Billion | 10 Billion | 50 Billion | 100 Billion Vials ​WJ-MSC-EXO in 2.5ml Saline in 5ml glass vial ​​​​Submit an order request form to receive a quote with discounted pricing on the 24 vial monthly subscription plan Also request info on bulk order distributor pricing Product Information and Use: For topical use only by professionals Animal Free Xeno-free Serum-free Made in USA "Off-The-Shelf" Solution Exosomes are not lyophilized but come cryo-frozen in saline, that means Easy to use - don't waste valuable professional time reconstituting the product (which is the required setup process to use lyophilized exosomes) Animal Cruelty Free - Never Tested on Animals Product Quality and Testing:​ Exosomes derived from mesenchymal stem cells from Wharton's jelly, which are from ethically donated human umbilical cords. All human umbilical cords are donated and screened in compliance with all USA Guidelines on Donor Testing and Screening Regulations Clinical grade tested per Stem Cell and Exosomes International Best Practices for Manufacturing & Quality guidelines at an independent US CLIA certified testing lab for infectious disease, sterility, endotoxin, bioburden and mycoplasma. Each lot is tested and released with a Certificate of Conformity with every shipment Every vial individually labeled for lot to lot traceability. No cell banking! Reporting characterization of CD63 & CD81 expression Exosome Size and Count measured and verified via NanoSight 300 Technology SDS available upon Requests Shipment:​ Domestic Ships UPS Next Day Air on dry ice ​​ International Shipments - please email to develop a logistics plan Shelf Life: 15 month shelf life from manufacturing date, when stored in -80 degree Celsius freezer 6 month shelf life from manufacturing date, when stored in -20 degree Celsius freezer 3 month shelf life from manufacturing date, when stored in refrigerator
  • What are the Key Ingredients in RESILIÉLLE'S Age-Zero™ Exosomes B-ELNs™ 
    RESILIÉLLE'S Age-Zero™ Exosomes B-ELNs™  (Biologics-Exosomes Lipids & Nanoscale Secretions): 99.9% Saline 0.1% B-ELNs™ (proteins, lipids, nucleic acids)
  • How are RESILIÉLLE Exosomes shipped, stored and what is the shelf life?
    Packed in 5ml glass vials with 2.5ml clinical grade saline and shipped on dry ice. Shipment: Domestic Shipments in dry ice domestically via UPS International Shipments in nitrogen cryoport or dry ice Shelf Life: 15 month shelf life from manufacturing date, when stored in -80 degree Celsius freezer 6 month shelf life from manufacturing date, when stored in -20 degree Celcius freezer 3 month shelf life from manufacturing date, when stored in refrigerator
  • What are the advantage of Exosomes vs Platelet Rich Plasma (PRP)?
    PRP is only as efficacious as the youth of the patient. Most adults receiving these treatments are forty and older. Blood drawn from that age group may not have rich enough platelets to be fully effective at restoring their hair through PRP injection therapy Unlike Exosomes, PRP have no antiinflammatory properties Age zero exosomes are consistent, quality tested and have controlled outcomes. PRP results vary based on age of patient Exosomes are applied topically are therefore pain-free, while PRP is acidic in nature and can cause significant discomfort Exosomes are 'off-the-shelf' and easy to use. Exosomes do not require patient blood draw. PRP takes extra prep time and additional equipment. PRP requires patient blood draw. Exosomes are non-invasive treatment option to the patient, whereas PRP is invasive Exosomes vs PRP in hair applications. PRP is used to stimulate and nourish follicles for hair growth. Highly concentrated plasma contains platelets that release growth factors; these growth factors have been shown to generate new hair and improve the density and health of your existing hair. Research shows that PRP not only decreases hair shedding and stimulates new hair growth, but it also increases the thickness of the hair follicle itself. It doesn’t’ help everybody, but it’s widely used with great success. Exosomes on the other hand - Now, just imagine rather than using whatever little bit of stimulating growth factors you can ‘harvest’ from a few milliliters of your own blood you use billions of exosomes, ready to go and fully packed with everything needed for regeneration. . . you judge for yourself as to what to expect.
  • What are Exosomes?
    Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new non-invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication. Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. Topical exosomes, although variable in source and method of isolation, are generally considered safe in humans on intact skin. The current published research literature does not yet provide a clear consensus on long-term use for skin rejuvenation or hair restoration, nor does it delineate which patients would benefit most from this technology. There are no currently US FDA-approved exosome products on the market for medical indications.
  • Are RESILIÉLLE Exosomes considered a topical solution?
    RESILIÉLLE Exosomes are tested to the following highest quality grade standards and processed in a cGMP facility: Resilielle Exosomes were designed to be the highest grade topical use cosmetic exosomes and Resilielle maintains the highest standards from US Tissue Sources to US Certified Lab testing Donor tissue screened and tested to 13 infectious diseases per US testing requirement guidelines. Final product is also tested at an independent US certified CLIA testing lab to the following tests: 13 Infectious diseases​ Sterility Endotoxin Bioburden Mycoplasma Reporting characterization of CD63 & CD81 expression Exosome size measured via NanoSight NS300 Each lot is release tested to with a final Certificate of Conformity sent with every shipment Every vial is individually labeled for lot to lot traceability
  • How are RESILIÉLLE Exosomes manufactured?
    Manufactured in partnership with leading US Stem Cell Manufacturing Experts in their state of the art, FDA HCT/P Registered, ISO Class 7 Clean Room, in compliance with an ISO 9001 Quality Management System. Animal Free and never tested on animals Xeno-free Serum-free No growth factors added To maintain the highest potency and shelf life, exosomes are stored frozen in Nitrogren Freezer and shipped on dry ice. Exosomes are never lyophilized, making them an "off-the-shelf" ready to use product. Lyophilized exosomes require the extra time of professionals to reconstitute the exosomes. Resilielle do not need to be reconstituted and are easy and ready to use straight from the vial. Available in exosomes derived from umbilical cord mesenchymal stem cells from Wharton's jelly, Age-Zero. All stem cells were expanded at low passage to maintain best-in-class cellular manufacturing processes as defined by the ISSCR recommendations An "Off-The-Shelf" nano acellular solution for regenerative cosmetics
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